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As such, one plausible mechanistic account is that repeated stimulation of high densities of nAChRs by nicotine may contribute to neurotoxicity within discrete regions and/or increase the vulnerability of those regions to other volatile compounds in tobacco smoke [19] which ultimately manifest as gray matter decreases

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"There've been theories and ideas around the fact that e-cigarettes may be helpful from a harm reduction perspective in helping people who are already on cigarettes (that) have had trouble quitting actually get off cigarettes," Murthy said